Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

K Michailidou; J Beesley; S Lindstrom; S Canisius; J Dennis; MJ Lush; MJ Maranian; MK Bolla; Q Wang; M Shah; BJ Perkins; K Czene; M Eriksson; H Darabi; JS Brand; SE Bojesen; BG Nordestgaard; H Flyger; SF Nielsen; N Rahman; C Turnbull; O Fletcher; J Peto; L Gibson; I Dos-Santos-Silva; J Chang-Claude; D Flesch-Janys; A Rudolph; U Eilber; S Behrens; H Nevanlinna; TA Muranen; K Aittomäki; C Blomqvist; S Khan; K Aaltonen; H Ahsan; MG Kibriya; AS Whittemore; EM John; KE Malone; MD Gammon; RM Santella; G Ursin; E Makalic; DF Schmidt; G Casey; DJ Hunter; SM Gapstur; MM Gaudet; WR Diver; CA Haiman; F Schumacher; BE Henderson; L Le Marchand; CD Berg; SJ Chanock; J Figueroa; RN Hoover; D Lambrechts; P Neven; H Wildiers; E Van Limbergen; MK Schmidt; A Broeks; S Verhoef; S Cornelissen; FJ Couch; JE Olson; E Hallberg; C Vachon; Q Waisfisz; H Meijers-Heijboer; MA Adank; RB Van Der Luijt; J Li; J Liu; K Humphreys; D Kang; JY Choi; SK Park; KY Yoo; K Matsuo; H Ito; H Iwata; K Tajima; P Guénel; T Truong; C Mulot; M Sanchez; B Burwinkel; F Marme; H Surowy; C Sohn; AH Wu; CC Tseng; D Van Den Berg; DO Stram; A González-Neira; J Benitez

Journal article

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

K Michailidou, J Beesley, S Lindstrom, S Canisius, J Dennis, MJ Lush, MJ Maranian, MK Bolla, Q Wang, M Shah, BJ Perkins, K Czene, M Eriksson, H Darabi, JS Brand, SE Bojesen, BG Nordestgaard, H Flyger, SF Nielsen, N Rahman Show all

Nature Genetics | Published : 2015

DOI: 10.1038/ng.3242

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Abstract

Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10 â ..

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University of Melbourne Researchers

Enes Makalic Author

Daniel Schmidt Author Melbourne School of Population and Global Health

Graham Giles Author

Alison Trainer Author

Related Projects (1)

THE KATHLEEN CUNNINGHAM FOUNDATION CONSORTIUM FOR RESEARCH INTO FAMILIAL BREAST CANCER

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

BCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme (BM0606). Genotyping on the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C8197/A16565), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program and the Ministry of Economic Development, Innovation and Export Trade of Quebec, grant PSR-SIIRI-701. Combination of the GWAS data was supported in part by the US National Institutes of Health (NIH) Cancer Post-Cancer GWAS initiative, grant 1 U19 CA148065-01 (DRIVE, part of the GAME-ON initiative). For a full description of funding and acknowledgments, see the the Supplementary Note.